Comment 1 Evidence-based practice (EBP) promotes quality, safe, and cost-effective outcomes for patients, families, healthcare providers, and the healthcare system. It evolves from the integration of the best research evidence with clinical expertise and patients’ needs and values (Grove, Gray & Burns, 2015. 5th ed). EBP incorporates the needs and values of the patient and the patient’s need(s) might focus on health promotion, illness prevention, acute or chronic illness management, rehabilitation, and/or a peaceful death. In addition, patients bring values or unique preferences, expectations, concerns, and cultural beliefs to the clinical encounter. With EBP, patients and their families are encouraged to take an active role in the management of their health values (Grove, Gray & Burns, 2015. 5th ed). Infection control in cancer patient with low immunity using evidence-based practice: Hand hygiene using soap and water or an antiseptic hand rub for all patients and their caregivers. Wearing protective gowns for expected body fluid contamination, use of gloves when contact with blood, body fluids, excretions, or secretions are expected. Limitation in the number of visitors and restrictions in visitors with symptoms of respiratory infection should be allowed. Environmental interventions such as keeping windows closed, using negative-pressure rooms, and using high-efficiency particulate air (HEPA) filters Contact precautions for patients known to be colonized or infected with resistant organisms (American Nurse Today, 2011). Evidence-based practices related to central-line patency: Needleless connectors with neutral/zero fluid displacement during access and de-access, prophylactic antimicrobial lock solutions instead of heparin or saline solution and standing orders for managing catheter occlusions (American Nurse Today, 2011). Comment 2 Through nursing research, empirical knowledge can be developed to improve nursing care, patient outcomes, and the healthcare delivery system. For example, nurses need a solid research base to implement and document the effectiveness of selected nursing interventions in treating particular patient problems and promoting positive patient and family outcomes. Also, nurses need to use research findings to determine the best way to deliver healthcare services to ensure that the greatest number of people receive quality, safe care. Our Hospital is currently trying to achieve the Magnet status. There has been a big push for nurses with an associate degree to earn their bachelor’s degree. You may be required to review the literature as part of a course assignment or project in the clinical setting, especially projects in Magnet hospitals. Nurses in Magnet hospitals must implement evidence-based practice, identify problems, and assist with data collection for research studies (American Nurses Credentialing Center [ANCC], 2013). Reviewing the literature is a first step in implementing evidence-based practice and identifying problems.